Unusual Corneal Sarcoidosis Manifestations

Ocul Immunol Inflamm. 2023 Jul;31(5):940-944. doi: 10.1080/09273948.2022.2071744. Epub 2022 May 6.

Abstract

Aim: To document atypical presenting forms of ocular sarcoidosis at the corneal level.

Methods: Case report.

Results: A 63-year-old woman presented multiple uncommon unilateral primary corneal conditions as manifestation of ocular sarcoidosis, including peripheral ulcerative keratitis, sterile corneal infiltrate (corneal granuloma), and sterile infiltrates related to a corneal foreign body, requiring medical and surgical management to control the inflammatory symptoms and to preserve the integrity of the eyeball. An excisional biopsy of a nodule in the temporal conjunctiva was performed under topical anesthesia. Histological analysis revealed a non-caseating granuloma, confirming the diagnosis of ocular sarcoidosis.

Conclusion: When thinking of ocular involvement in patients with ocular sarcoidosis, it is essential to remember that manifestations such as peripheral ulcerative keratitis, sterile corneal infiltrate, and sterile foreign body-related infiltrates may be presentations of this disease.

Keywords: Corneal granuloma; corneal surgery; ocular sarcoidosis; sarcoidosis; ulcerative keratitis.

Publication types

  • Case Reports

MeSH terms

  • Cornea
  • Corneal Diseases* / diagnosis
  • Corneal Diseases* / etiology
  • Corneal Ulcer* / diagnosis
  • Female
  • Humans
  • Middle Aged
  • Sarcoidosis* / complications
  • Sarcoidosis* / diagnosis