Biocompatible ionic liquid [Betaine][H2PO4] as a reusable catalyst for the substitution of xanthen-9-ol under solvent-free conditions

Anlian Zhu; Tong Wang; Wanlu Feng; Jianji Wang; Lingjun Li

doi:10.1039/d0ra05374k

Biocompatible ionic liquid [Betaine][H₂PO₄] as a reusable catalyst for the substitution of xanthen-9-ol under solvent-free conditions

RSC Adv. 2020 Aug 27;10(52):31662-31669. doi: 10.1039/d0ra05374k. eCollection 2020 Aug 21.

Authors

Anlian Zhu¹, Tong Wang¹, Wanlu Feng¹, Jianji Wang¹, Lingjun Li¹

Affiliation

¹ School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Normal University Xinxiang Henan 453007 P. R. China alzhuchem@126.com lingjunlee@htu.cn.

Abstract

An ionic liquid, namely [Betaine][H₂PO₄], was found to be an efficient catalyst for the direct substitution reaction of xanthen-9-ol with different nucleophiles under solvent-free conditions. This catalytic system is easy to be operated and the following work-up procedure is simple, with the ionic liquid catalyst reusable for at least five cycles at a high catalytic activity level. In addition, the ionic liquid is easy to prepare and its raw materials are inexpensive and have good biocompatibility. Therefore, our study presents an intriguing and sustainable protocol for the direct substitution of alcohol.