A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

Artur Kasprzak; Bartłomiej Dabrowski; Agnieszka Zuchowska

doi:10.1039/d0ra03694c

A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

RSC Adv. 2020 Jun 19;10(39):23440-23445. doi: 10.1039/d0ra03694c. eCollection 2020 Jun 16.

Authors

Artur Kasprzak¹, Bartłomiej Dabrowski¹, Agnieszka Zuchowska¹

Affiliation

¹ Faculty of Chemistry, Warsaw University of Technology Noakowskiego Str. 3 00-664 Warsaw Poland akasprzak@ch.pw.edu.pl.

Abstract

Facile and efficient methods for the synthesis of the first poly(aminodamine) PAMAM G1.0 dendrimer octa-substituted with α-cyclodextrin and a novel ferrocenyl prodrug of doxorubicin hydrochloride are developed. This vector is non-toxic and can bind the designed ferrocenyl prodrug. It also shows a controlled drug release profile and high cytotoxicity against breast cancer cells (MCF-7), as elucidated by the in vitro biological studies performed with an innovative cell-on-a-chip microfluidic system.