A nickel-catalyzed tandem reaction involving cyclic esterification/C-S bond formation for synthesizing 5-oxa-11-thia-benzofluoren-6-ones

Rongrong Cai; Qicai Wei; Runsheng Xu

doi:10.1039/d0ra04367b

A nickel-catalyzed tandem reaction involving cyclic esterification/C-S bond formation for synthesizing 5-oxa-11-thia-benzofluoren-6-ones

RSC Adv. 2020 Jul 14;10(44):26414-26417. doi: 10.1039/d0ra04367b. eCollection 2020 Jul 9.

Authors

Rongrong Cai¹, Qicai Wei¹, Runsheng Xu¹

Affiliation

¹ Department of Biology and Environment, Jiyang College of Zhejiang A&F University Shaoxing 311800 Zhejiang China 20140041@zafu.edu.cn.

Abstract

A nickel-catalyzed tandem reaction involving cyclic esterification/C-S bond formation has been developed. Starting from samples containing 3-(2-hydroxy-phenyl)-acrylic acids with 2-halide-benzenethiols, versatile biologically active 5-oxa-11-thia-benzofluoren-6-one compounds were efficiently synthesized in good to high yields. This new methodology provides an economical approach toward C-S bond formation.