Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases

K Y Saw; A W Anz; Csy Jee; A Ramlan; A Dawam; S F Low

doi:10.5704/MOJ.2203.022

Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases

Malays Orthop J. 2022 Mar;16(1):134-137. doi: 10.5704/MOJ.2203.022.

Authors

K Y Saw¹, A W Anz², Csy Jee³, A Ramlan³, A Dawam³, S F Low⁴

Affiliations

¹ Department of Orthopaedic Surgery, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia.
² Department of Orthopaedics, Andrews Institute for Orthopaedics and Sports Medicine, Gulf Breeze, United States.
³ Stem Cells R&D, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia.
⁴ Department of Radiology, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia.

Abstract

End-stage ankle arthritis represents an "unmet medical need", awaiting an appropriate time for joint arthroplasty or arthrodesis. We report three cases of end-stage ankle arthritis treated along the principles developed for chondrogenesis of the knee joint with autologous peripheral blood stem cells, resulting in reversal of the ankle arthritis. The improvement in clinical outcome measure scores (Ankle Osteoarthritis Scale total score) with a minimum two-year follow-up were comparable to total ankle replacement (TAR), arthroscopic ankle arthrodesis (AAA) and open ankle arthrodesis (OAA).

Keywords: chondrogenesis; end-stage ankle arthritis; marrow stimulation; massive chondral defects; peripheral blood stem cells.

Publication types

Case Reports