Rhizovagine A, an unusual dibenzo-α-pyrone alkaloid from the endophytic fungus Rhizopycnis vagum Nitaf22

Ali Wang; Siji Zhao; Gan Gu; Dan Xu; Xuping Zhang; Daowan Lai; Ligang Zhou

doi:10.1039/d0ra05022a

Rhizovagine A, an unusual dibenzo-α-pyrone alkaloid from the endophytic fungus Rhizopycnis vagum Nitaf22

RSC Adv. 2020 Jul 27;10(47):27894-27898. doi: 10.1039/d0ra05022a.

Authors

Ali Wang¹, Siji Zhao¹, Gan Gu¹, Dan Xu¹, Xuping Zhang¹, Daowan Lai¹, Ligang Zhou¹

Affiliation

¹ Department of Plant Pathology, College of Plant Protection, China Agricultural University Beijing 100193 China dwlai@cau.edu.cn lgzhou@cau.edu.cn.

Abstract

Rhizovagine A (1), a novel dibenzo-α-pyrone alkaloid with an unprecedented 5/5/6/6/6 fused pentacyclic skeleton, was isolated from the endophytic fungus Rhizopycnis vagum Nitaf22. The structure was elucidated by comprehensive spectroscopic analysis, in combination with quantum chemical ¹³C NMR and electronic circular dichroism (ECD) calculations for configurational assignment. A plausible biosynthetic pathway for 1 was proposed. Compound 1 displayed acetylcholinesterase inhibitory activity.