Microglia: The Hub of Intercellular Communication in Ischemic Stroke

Yunsha Zhang; Lu Lian; Rong Fu; Jueling Liu; Xiaoqian Shan; Yang Jin; Shixin Xu

doi:10.3389/fncel.2022.889442

Microglia: The Hub of Intercellular Communication in Ischemic Stroke

Front Cell Neurosci. 2022 Apr 18:16:889442. doi: 10.3389/fncel.2022.889442. eCollection 2022.

Authors

Yunsha Zhang¹, Lu Lian^{2

3

4}, Rong Fu^{2

3

4}, Jueling Liu^{2

3

4}, Xiaoqian Shan^{2

3

4}, Yang Jin¹, Shixin Xu^{2

4

5}

Affiliations

¹ School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine Tianjin, China.
² Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin, China.
³ Tianjin University of Traditional Chinese Medicine, Tianjin, China.
⁴ National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
⁵ Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin, China.

Abstract

Communication between microglia and other cells has recently been at the forefront of research in central nervous system (CNS) disease. In this review, we provide an overview of the neuroinflammation mediated by microglia, highlight recent studies of crosstalk between microglia and CNS resident and infiltrating cells in the context of ischemic stroke (IS), and discuss how these interactions affect the course of IS. The in-depth exploration of microglia-intercellular communication will be beneficial for therapeutic tools development and clinical translation for stroke control.

Keywords: intercellular communication; ischemic stroke; microglia; microglia polarization; neuroinflammation.

Publication types

Review