Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system

Javier Águila-Rosas; Tomás Quirino-Barreda; Gerardo Leyva-Gómez; Eduardo González-Zamora; Ilich A Ibarra; Enrique Lima

doi:10.1039/d0ra03636f

Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system

RSC Adv. 2020 Jul 7;10(43):25645-25651. doi: 10.1039/d0ra03636f. eCollection 2020 Jul 3.

Authors

Javier Águila-Rosas^{1

2}, Tomás Quirino-Barreda¹, Gerardo Leyva-Gómez³, Eduardo González-Zamora⁴, Ilich A Ibarra^{5

6}, Enrique Lima⁵

Affiliations

¹ Laboratorio de Farmacia Molecular y Liberación Controlada, UAM-Xochimilco Calzada del Hueso 1100, Col. Villa Quietud CP 04960 CDMX Mexico.
² Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, UAM-Xochimilco Calzada del Hueso 1100, Col. Villa Quietud CP 04960, CDMX Mexico.
³ Facultad de Química, Universidad Nacional Autónoma de México Circuito Exterior s/n, Cd. Universitaria, Del. Coyoacán CP 04510 CDMX Mexico.
⁴ Universidad Autónoma Metropolitana-Iztapalapa San Rafael Atlixco 186, Col. Vicentina, Iztapalapa Ciudad de México CP 09340 Mexico.
⁵ Laboratorio de Fisicoquímica y Reactividad de Superficies (LaFReS), Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México Circuito Exterior s/n, Cd. Universitaria, Del. Coyoacán CP 04510 CDMX Mexico argel@unam.mx lima@iim.unam.mx +52-55-5622-4595.
⁶ Pharma View Consulting SC CDMX Mexico.

Abstract

Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal-organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine-MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored in vitro and ex vivo conditions. A kinetic release model is proposed for in vitro sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.