Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines

Sergey A Rzhevskiy; Alexandra A Ageshina; Gleb A Chesnokov; Pavel S Gribanov; Maxim A Topchiy; Mikhail S Nechaev; Andrey F Asachenko

doi:10.1039/c8ra10040c

Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines

RSC Adv. 2019 Jan 11;9(3):1536-1540. doi: 10.1039/c8ra10040c. eCollection 2019 Jan 9.

Authors

Sergey A Rzhevskiy^{1

2}, Alexandra A Ageshina¹, Gleb A Chesnokov^{1

2}, Pavel S Gribanov^{1

3}, Maxim A Topchiy^{1

2}, Mikhail S Nechaev^{1

2}, Andrey F Asachenko^{1

2}

Affiliations

¹ A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Leninsky Prospect 29 Moscow 119991 Russia aasachenko@ips.ac.ru.
² M.V. Lomonosov Moscow State University Leninskie Gory 1 (3) Moscow 119991 Russia m.s.nechaev@org.chem.msu.ru.
³ A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences Vavilov str. 28 Moscow 119991 Russian Federation.

Abstract

A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.