Synthesis of polyhydroquinolines and propargylamines through one-pot multicomponent reactions using an acidic ionic liquid immobilized onto magnetic Fe3O4 as an efficient heterogeneous catalyst under solvent-free sonication

Hai Truong Nguyen; Vy Anh Truong; Phuong Hoang Tran

doi:10.1039/d0ra04008h

Synthesis of polyhydroquinolines and propargylamines through one-pot multicomponent reactions using an acidic ionic liquid immobilized onto magnetic Fe₃O₄ as an efficient heterogeneous catalyst under solvent-free sonication

RSC Adv. 2020 Jul 3;10(42):25358-25363. doi: 10.1039/d0ra04008h. eCollection 2020 Jun 29.

Authors

Hai Truong Nguyen^{1

2}, Vy Anh Truong^{1

2}, Phuong Hoang Tran^{1

2}

Affiliations

¹ Department of Organic Chemistry, Faculty of Chemistry, University of Science Ho Chi Minh City 721337 Vietnam thphuong@hcmus.edu.vn.
² Vietnam National University Ho Chi Minh City 721337 Vietnam.

Abstract

A nano-sized Fe₃O₄-supported Lewis acid ionic liquid catalyst for the synthesis of polyhydroquinolines and propargylamines under ultrasound irradiation has been developed. LAIL@MNP was synthesized from imidazolium chlorozincate(ii) ionic liquid grafted onto the surface of Fe₃O₄ nanoparticles and evaluated by FT-IR, TGA, SEM, Raman, TEM, ICP-OES, and EDS. The multicomponent synthesis of polyhydroquinolines and propargylamines proceeded smoothly to afford the desired products in high yields. LAIL@MNP can be separated easily from the reaction mixture and reused for several runs without a significant degradation in catalytic activity.