Two decades of the synthesis of mono- and bis-aminomercapto[1,2,4]triazoles

Sayed M Riyadh; Sobhi M Gomha

doi:10.1039/d0ra04208k

Two decades of the synthesis of mono- and bis-aminomercapto[1,2,4]triazoles

RSC Adv. 2020 Jul 1;10(42):24994-25012. doi: 10.1039/d0ra04208k. eCollection 2020 Jun 29.

Authors

Sayed M Riyadh^{1

2}, Sobhi M Gomha^{2

3}

Affiliations

¹ Department of Chemistry, Faculty of Science, Taibah University Al-Madinah Al-Munawarah 30002 Saudi Arabia.
² Department of Chemistry, Faculty of Science, Cairo University Giza 12613 Egypt s.m.gomha@gmail.com.
³ Department of Chemistry, Faculty of Science, Islamic University in Al-Madinah Al-Munawarah 42351 Saudi Arabia.

Abstract

4-Amino-5-mercapto[1,2,4]triazole and its 3-substituted derivatives have proven to be of biological interest and provide access to a new class of biologically active heterocyclic compounds for biomedical applications. This study will be helpful for scientific researchers interested in the chemistry of bifunctional versatile compounds as it provides a collection of all the methods for the preparation of 3-substituted-4-amino-5-mercapto[1,2,4]triazoles with aliphatic, aromatic, and heterocyclic moieties during the period from 2000 to mid-2020.

Publication types

Review