Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials

RSC Adv. 2020 Jun 22;10(40):23675-23681. doi: 10.1039/d0ra03659e. eCollection 2020 Jun 19.

Abstract

We report the development and use of a light-mediated in situ grafting technology for the surface modification of biosynthetic corneal implants with peptide-capped nanoparticles (15-65 nm). The resulting materials have antimicrobial properties in bacterial suspension and also reduced the extent of biofilm formation. Our in situ grafting technology offers a rapid route for the introduction of antimicrobial properties to premoulded corneal implants, and potentially other soft implant targets.