Pseudonectrins A-D, heptaketides from an endophytic fungus Nectria pseudotrichia

Peinan Fu; Tingnan Zhou; Fengxia Ren; Shuaiming Zhu; Yang Zhang; Wenying Zhuang; Yongsheng Che

doi:10.1039/c9ra01787a

Pseudonectrins A-D, heptaketides from an endophytic fungus Nectria pseudotrichia

RSC Adv. 2019 Apr 17;9(21):12146-12152. doi: 10.1039/c9ra01787a. eCollection 2019 Apr 12.

Authors

Peinan Fu^{1

2}, Tingnan Zhou^{1

2}, Fengxia Ren², Shuaiming Zhu², Yang Zhang², Wenying Zhuang³, Yongsheng Che^{2

4}

Affiliations

¹ School of Medicine and Life Sciences, Nanjing University of Chinese Medicine Nanjing 210023 People's Republic of China.
² State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology Beijing 100850 People's Republic of China cheys@im.ac.cn zhangyang@bmi.ac.cn.
³ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences Beijing 100101 People's Republic of China.
⁴ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 People's Republic of China.

Abstract

Four new heptaketides, pseudonectrins A-D (1-4), and four known compounds (5-8) were isolated from cultures of an endophytic fungus Nectria pseudotrichia. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1-3 and 4 were assigned by electronic circular dichroism calculations and the modified Mosher method, respectively. Compound 1-3 showed moderate cytotoxicity, with IC₅₀ values of 11.6-41.2 μM.