Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto

Norihiro Okada; Kenshiro Oshima; Yuki Iwasaki; Akiko Maruko; Kenya Matsumura; Erica Iioka; Trieu-Duc Vu; Naoki Fujitsuka; Akinori Nishi; Aiko Sugiyama; Mitsue Nishiyama; Atsushi Kaneko; Kazushige Mizoguchi; Masahiro Yamamoto; Susumu Nishimura

doi:10.1016/j.dib.2022.108197

Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto

Data Brief. 2022 Apr 22:42:108197. doi: 10.1016/j.dib.2022.108197. eCollection 2022 Jun.

Authors

Norihiro Okada^{1

2

3}, Kenshiro Oshima^{1

2}, Yuki Iwasaki^{2

3}, Akiko Maruko^{1

2}, Kenya Matsumura¹, Erica Iioka², Trieu-Duc Vu^{1

2}, Naoki Fujitsuka⁴, Akinori Nishi⁴, Aiko Sugiyama⁴, Mitsue Nishiyama⁴, Atsushi Kaneko⁴, Kazushige Mizoguchi⁴, Masahiro Yamamoto⁴, Susumu Nishimura^{2

5}

Affiliations

¹ School of Pharmacy, Kitasato University, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252- 0373 Japan.
² Foundation for Advancement of International Science (FAIS) , 3-24-16 Kasuga, Tsukuba, Ibaraki 305-0821 Japan.
³ Nagahama Institute of Bio-Science and Technology, Nagahama, Japan.
⁴ Tsumura Kampo Research Laboratories, Tsumura & CO., 3586 Yoshiwara, Ami-machi, Ibaraki 300- 1192 Japan.
⁵ Laboratory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305- 8575 Japan.

Abstract

We performed RNA-seq analyses of mRNA isolated from five organs, liver, bone, heart, kidney and blood at the pre-symptomatic state of klotho mice with/without administration of a Japanese traditional herbal medicine, juzentaihoto (JTT). Data of differentially expressed genes (DEG) with/without JTT was included. Intron retention (IR) is an important regulatory mechanism that affects gene expression and protein functions. We collected data in which retained-introns were accumulated in a particular set of genes of these organs, and showed that among these retained introns in the liver and bone a subset was recovered to the normal state by the medicine. All of the data present changes of molecular events on the levels of metabolites, proteins and gene expressions observed at the pre- symptomatic state of aging in klotho mice with/without JTT. The research article related to this Data in Brief is published in GENE entitled as "Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese herbal medicine".

Keywords: Aging; Alternative splicing; Intron retention; Japanese herbal medicine; Kampo; Pre-symptomatic state; RNA-seq.