The COVID-19 pandemic has been inflicted upon humanity by the SARS-CoV-2 virus, the latest insidious incarnation of the coronaviruses group. While in its wake intense scientific research has produced breakthrough vaccines and cures, there still exists an immediate need to further understand the origin, mechanobiology and biochemistry, and destiny of this virus so that future pandemics arising from similar coronaviruses may be contained more effectively. In this Perspective, we discuss the various evidential findings of virus propagation and connect them to respective underpinning cellular biomechanical states leading to corresponding manifestations of the viral activity. We further propose avenues to tackle the virus, including from a "musical" vantage point, and contain its relentless strides that are currently afflicting the global populace.
Keywords: ACE2; COVID-19; Cobicistat; D614G; Darunavir; Egmont; GSH; GSSG; Lopinavir; Remdesivir; Ritonavir; SARS-CoV-2; disulfide; dorian; endocytosis; hydrogen bonds; lipid rafts; mechanobiology; music; peptide; piezoelectricity; spikes; vaccines.