Krebs takes a turn at cell differentiation

Stanisław Deja; Peter A Crawford; Shawn C Burgess

doi:10.1016/j.cmet.2022.04.005

Krebs takes a turn at cell differentiation

Cell Metab. 2022 May 3;34(5):658-660. doi: 10.1016/j.cmet.2022.04.005.

Authors

Stanisław Deja¹, Peter A Crawford², Shawn C Burgess³

Affiliations

¹ Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
² Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
³ Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: shawn.burgess@utsouthwestern.edu.

PMID: 35508108
DOI: 10.1016/j.cmet.2022.04.005

Abstract

In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

Publication types

Comment

MeSH terms

Animals
Cell Differentiation
Citrates* / metabolism
Citric Acid
Citric Acid Cycle*
Mice
Oxidation-Reduction

Substances

Citrates
Citric Acid

Abstract

Publication types

MeSH terms

Substances

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