A smartphone-based three-in-one biosensor for co-detection of SARS-CoV-2 viral RNA, antigen and antibody

Yanzhi Dou; Jing Su; Shixing Chen; Tie Li; Lihua Wang; Xianting Ding; Shiping Song; Chunhai Fan

doi:10.1039/d2cc01297a

A smartphone-based three-in-one biosensor for co-detection of SARS-CoV-2 viral RNA, antigen and antibody

Chem Commun (Camb). 2022 May 20;58(41):6108-6111. doi: 10.1039/d2cc01297a.

Authors

Yanzhi Dou^{1

2}, Jing Su³, Shixing Chen⁴, Tie Li⁴, Lihua Wang⁵, Xianting Ding³, Shiping Song⁵, Chunhai Fan^{1

6}

Affiliations

¹ Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China.
² University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
³ State Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University Shanghai 200030, China. dingxianting@sjtu.edu.cn.
⁴ Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
⁵ The Interdisciplinary Research Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, P. R. China. songsp@sari.ac.cn.
⁶ Institute of Molecular Medicine, Renji Hospital, School of Medicine and School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.

PMID: 35506357
DOI: 10.1039/d2cc01297a

Abstract

Rapid and comprehensive diagnostic methods are necessary for early identification and monitoring of SARS-CoV-2. Here, we have developed a universal and portable three-in-one biosensor linked to a smartphone for co-detection of SARS-CoV-2 viral RNA, antigen, and antibody. In combination with a smartphone, the online monitoring of SARS-CoV-2 virus-infected patients from infection to immunization could be intelligently achieved.

MeSH terms

Antibodies, Viral
Biosensing Techniques*
COVID-19* / diagnosis
Humans
RNA, Viral / genetics
SARS-CoV-2
Smartphone

Substances

Antibodies, Viral
RNA, Viral