Study on the mechanism of Mycoplasma gallisepticum infection on chicken tracheal mucosa injury

Chunlin Wu; Lemiao Zhong; Ligen Zhang; Wenji Li; Binhui Liu; Baoqin Huang; Zhongbao Luo; Yijian Wu

doi:10.1080/03079457.2022.2068997

Study on the mechanism of Mycoplasma gallisepticum infection on chicken tracheal mucosa injury

Avian Pathol. 2022 Aug;51(4):361-373. doi: 10.1080/03079457.2022.2068997. Epub 2022 Jun 27.

Authors

Chunlin Wu¹, Lemiao Zhong¹, Ligen Zhang¹, Wenji Li², Binhui Liu^{1

3}, Baoqin Huang^{1

4}, Zhongbao Luo^{1

4}, Yijian Wu^{1

5}

Affiliations

¹ College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China.
² ZooKo Biochec Technology Co. Ltd, Nanping, People's Republic of China.
³ Fujian Vocational College of Agriculture, Fuzhou, People's Republic of China.
⁴ Fujian Sunner Development Co. Ltd, Nanping, People's Republic of China.
⁵ Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal 10 Health (Fujian Agricultural and Forestry University), Fuzhou, People's Republic of China.

PMID: 35503522
DOI: 10.1080/03079457.2022.2068997

Abstract

RESEARCH HIGHLIGHTSMG infection causes a persistent inflammatory response by increasing the expression of immune response genes.The ERK-MLCK signalling pathway activated by MG infection regulates tight junction proteins in the tracheal mucosa.These data provide a basis for future prevention and treatment studies to control MG infection.

Keywords: Mycoplasma gallisepticum; PET-MLCK signaling pathway; immunohistochemistry; tight junction; transcriptome.

MeSH terms

Animals
Chickens
Mucous Membrane
Mycoplasma Infections* / veterinary
Mycoplasma gallisepticum*
Poultry Diseases*