Research on biochemical indexes of bone metabolism in bipolar disorder: A cross-sectional study with newly diagnosed, drug-naïve patients

Sujuan Li; Yan Qiu; Ziwei Teng; Baoyan Xu; Hui Tang; Hui Xiang; Xuelei Xu; Jindong Chen; Jieyu Liu; Bolun Wang; Hui Yuan; Haishan Wu

doi:10.1016/j.jpsychires.2022.04.015

Research on biochemical indexes of bone metabolism in bipolar disorder: A cross-sectional study with newly diagnosed, drug-naïve patients

J Psychiatr Res. 2022 Jul:151:197-204. doi: 10.1016/j.jpsychires.2022.04.015. Epub 2022 Apr 25.

Authors

Sujuan Li¹, Yan Qiu¹, Ziwei Teng¹, Baoyan Xu¹, Hui Tang¹, Hui Xiang¹, Xuelei Xu¹, Jindong Chen¹, Jieyu Liu², Bolun Wang³, Hui Yuan⁴, Haishan Wu⁵

Affiliations

¹ National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
² Department of Ultrasound Dltrasound Diagnosis, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
³ Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
⁴ Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: yhnice@csu.edu.cn.
⁵ National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. Electronic address: wuhaishan@csu.edu.cn.

PMID: 35500447
DOI: 10.1016/j.jpsychires.2022.04.015

Abstract

Background: In recent years, the metabolic abnormalities associated with bipolar disorder (BD) have attracted people's attention. However, clinical studies on bone metabolism in individuals with BD are unavailable. This study was designed to assess biochemical indexes of bone metabolism and related influencing factors.

Methods: We measured bone turnover markers (BTMs), including procollagen Ⅰ N-terminal propeptide (PⅠNP), osteocalcin (OC) and C-terminal cross-linking telopeptide of type I collagen (CTX-I), and index of calcium and phosphorus metabolism in 100 drug-naïve individuals with BD (DSM-5) and 91 healthy volunteers. Besides, sociodemographic and clinical assessment were collected. Between-group comparisons and within subgroup analysis were performed.

Results: The PⅠNP (t = 3.715, p < 0.001), OC (t = 2.117, p = 0.036), parathyroid hormone (PTH, t = 3.877, p < 0.001), vitamin D (t = 2.065, p = 0.041), insulin (t = 4.208, p < 0.001) and insulin resistance (t = 2.888, p = 0.004) levels in the drug-naive BD group was significantly higher than those in the healthy control (HC) group. The level of calcium (t = -2.124, p = 0.035) in the drug-naive BD group was significantly lower than that of the HC group. But OC and vitamin D loses statistical significance after Bonferroni correction. However, there was no significant difference in the CTX-I level between the two groups. There are gender differences in the level of BMTs in individuals with BD, but this phenomenon was not found in the HC subgroup. It is shown that diagnosed BD, gender, age and BMI may affect the PINP levels through multiple linear regression analysis.

Conclusion: The biochemical indexes of bone metabolism in drug-naive individuals with BD were more active than that of the healthy controls in a sample from the Chinese Han nationality. The finding provides new evidence for our understanding of bone metabolism in individuals with BD.

Keywords: Bipolar disorder; Bone turnover markers (BTMs); Drug-naïve; Parathyroid hormone (PTH); Vitamin D.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers / metabolism
Bipolar Disorder*
Bone Remodeling*
Calcium
Cross-Sectional Studies
Humans
Peptide Fragments / metabolism
Vitamin D

Substances

Biomarkers
Peptide Fragments
Vitamin D
Calcium