Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy

Lamiaa M A Ali; Emna Mathlouthi; Maëlle Cahu; Saad Sene; Morgane Daurat; Jérôme Long; Yannick Guari; Fabrice Salles; Joël Chopineau; Jean-Marie Devoisselle; Joulia Larionova; Magali Gary-Bobo

doi:10.1039/c9ra09133e

Synergic effect of doxorubicin release and two-photon irradiation of Mn²⁺-doped Prussian blue nanoparticles on cancer therapy

RSC Adv. 2020 Jan 15;10(5):2646-2649. doi: 10.1039/c9ra09133e. eCollection 2020 Jan 14.

Authors

Affiliations

¹ Institut des Biomolécules Max Mousseron, UMR5247, Université de Montpellier, CNRS, ENSCM, Faculté de Pharmacie 15 Avenue Charles Flahault 34093 Montpellier Cedex 05 France magali.gary-bobo@inserm.fr.
² Department of Biochemistry, Medical Research Institute, University of Alexandria Alexandria Egypt.
³ Institut Charles Gerhardt, Université de Montpellier, CNRS, ENSCM Place Eugène Bataillon 34095 Montpellier Cedex 5 France joulia.larionova@umontpellier.fr.
⁴ Université de Tunis el Manar, Faculté des Sciences, UR/11/ES/19, Physico-chimie des matériaux à l'état condensé 2092 Tunis Tunisia.
⁵ NanoMedSyn 15 Avenue Charles Flahault 34093 Montpellier France.

Abstract

We demonstrate here that Mn²⁺-doped Prussian blue nanoparticles of ca. 55 nm loaded with doxorubicin may be used as efficient therapeutic agents for combined photothermal and chemo-therapy of cancer cells with a synergic effect under two photon irradiation.