Synthesis of new N, N'-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of their in vitro anticancer activity

Vnira R Akhmetova; Nail S Akhmadiev; Marat F Abdullin; Lilya U Dzhemileva; Vladimir A D'yakonov

doi:10.1039/c9ra09783j

Synthesis of new N, N'-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of their in vitro anticancer activity

RSC Adv. 2020 Apr 17;10(26):15116-15123. doi: 10.1039/c9ra09783j. eCollection 2020 Apr 16.

Authors

Vnira R Akhmetova¹, Nail S Akhmadiev¹, Marat F Abdullin², Lilya U Dzhemileva¹, Vladimir A D'yakonov¹

Affiliations

¹ Institute of Petrochemistry and Catalysis, Russian Academy of Sciences 141 Prospekt Oktyabrya 450075 Ufa Russian Federation vnirara@mail.ru +7 3472 842750 +7 3472 842750.
² Ufa Institute of Chemistry, Russian Academy of Sciences 71 Prospekt Oktyabrya 450054 Ufa Russian Federation.

Abstract

The synthesis of new N,N'-mononuclear bi-ligand Pd(ii) and tri-ligand Pt(ii)complexes bearing sulfanyl(phenyl, benzyl, cyclohexyl, 4-hydroxyphenyl)3,5-dimethyl-1H-pyrazole ligands has been carried out. The obtained compounds were studied for apoptosis-inducing activity and effect on the cell cycle for Jurkat, K562, and U937 neoplastic cell cultures and conditionally normal human embryonic kidney HEK293 cells. The cells showed the highest sensitivity to platinum and palladium complexes in comparison with ligands and cisplatin. The cytotoxic properties are enhanced for compounds with cyclohexyl substituents at the S-atom in sulfanyl pyrazoles and complexes.