Sarcosenones A-C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp

Xintong Hou; Yang Xu; Shuaiming Zhu; Yang Zhang; Liangdong Guo; Feng Qiu; Yongsheng Che

doi:10.1039/d0ra02485f

Sarcosenones A-C, highly oxygenated pimarane diterpenoids from an endolichenic fungus Sarcosomataceae sp

RSC Adv. 2020 Apr 22;10(26):15622-15628. doi: 10.1039/d0ra02485f. eCollection 2020 Apr 16.

Authors

Xintong Hou^{1

2}, Yang Xu², Shuaiming Zhu³, Yang Zhang³, Liangdong Guo⁴, Feng Qiu¹, Yongsheng Che^{1

2}

Affiliations

¹ Tianjin University of Traditional Chinese Medicine Tianjin 300193 People's Republic of China.
² Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 People's Republic of China cheys@im.ac.cn.
³ State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology Beijing 100850 People's Republic of China zhangyang@bmi.ac.cn.
⁴ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences Beijing 100101 People's Republic of China.

Abstract

Three new highly oxygenated pimarane diterpenoids, sarcosenones A-C (1-3), and the known 9α-hydroxy-1,8(14),15-isopimaratrien-3,7,11-trione (4), were isolated from cultures of an endolichenic fungus Sarcosomataceae sp. Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compound 1 showed moderate cytotoxicity against a small panel of four human tumor cell lines, with IC₅₀ values of 7.5-26.4 μM.