Resilience integrates concepts in aging research

Daniel Promislow; Rozalyn M Anderson; Marten Scheffer; Bernard Crespi; James DeGregori; Kelley Harris; Barbara Natterson Horowitz; Morgan E Levine; Maria A Riolo; David S Schneider; Sabrina L Spencer; Dario Riccardo Valenzano; Michael E Hochberg

doi:10.1016/j.isci.2022.104199

Resilience integrates concepts in aging research

iScience. 2022 Apr 6;25(5):104199. doi: 10.1016/j.isci.2022.104199. eCollection 2022 May 20.

Authors

Daniel Promislow^{1

2}, Rozalyn M Anderson^{3

4}, Marten Scheffer^{5

6}, Bernard Crespi⁷, James DeGregori⁸, Kelley Harris⁹, Barbara Natterson Horowitz¹⁰, Morgan E Levine¹¹, Maria A Riolo⁶, David S Schneider¹², Sabrina L Spencer¹³, Dario Riccardo Valenzano^{14

15}, Michael E Hochberg^{6

16}

Affiliations

¹ Department of Lab Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.
² Department of Biology, University of Washington, Seattle, WA 98195, USA.
³ Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA.
⁴ GRECC, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.
⁵ Department of Aquatic Ecology and Water Quality Management, Wageningen University, Wageningen, the Netherlands.
⁶ Santa Fe Institute, Santa Fe, NM 87501, USA.
⁷ Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
⁸ Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
⁹ Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
¹⁰ Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
¹¹ Department of Pathology, Yale University School of Medicine, New Haven, CT 06524, USA.
¹² Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
¹³ Department of Biochemistry and BioFrontiers Institute, University of Colorado-Boulder, Boulder, CO 80303, USA.
¹⁴ Max Planck Institute for Biology of Ageing, Cologne, Germany.
¹⁵ CECAD, University of Cologne, Cologne, Germany.
¹⁶ ISEM, Université de Montpellier, CNRS, IRD, EPHE, Montpellier, 34095 France.

Abstract

Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite a common focus to advance our understanding of aging, these disciplines have proceeded along distinct paths with little cross-talk. We propose that the concept of resilience can bridge this gap. Resilience describes the ability of a system to respond to perturbations by returning to its original state. Although resilience has been applied in a few individual disciplines in aging research such as frailty and cognitive decline, it has not been explored as a unifying conceptual framework that is able to connect distinct research fields. We argue that because a resilience-based framework can cross broad physiological levels and time scales it can provide the missing links that connect these diverse disciplines. The resulting framework will facilitate predictive modeling and validation and influence targets and directions in research on the biology of aging.

Keywords: Biological sciences; Cell biology; Evolutionary biology; Health sciences; Molecular biology.

Publication types

Review

Abstract

Publication types

Grants and funding