Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water

Yajie Fu; Zeping Lu; Ke Fang; Xinyi He; Huajin Xu; Yi Hu

doi:10.1039/c9ra10014h

Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water

RSC Adv. 2020 Mar 16;10(18):10848-10853. doi: 10.1039/c9ra10014h. eCollection 2020 Mar 11.

Authors

Yajie Fu¹, Zeping Lu¹, Ke Fang¹, Xinyi He¹, Huajin Xu¹, Yi Hu¹

Affiliation

¹ State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University Nanjing 210009 China huyi@njtech.edu.cn dg1224097@smail.nju.edu.cn.

Abstract

A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up.