Crystal structure of 1 H-imidazole-1-methanol

Megan M Wysocki; Gorana Puzovic; Keith L Dowell; Eric W Reinheimer; Deidra L Gerlach

doi:10.1107/S2056989022002614

Crystal structure of 1 H-imidazole-1-methanol

Acta Crystallogr E Crystallogr Commun. 2022 Mar 10;78(Pt 4):377-380. doi: 10.1107/S2056989022002614. eCollection 2022 Apr 1.

Authors

Megan M Wysocki¹, Gorana Puzovic¹, Keith L Dowell¹, Eric W Reinheimer², Deidra L Gerlach¹

Affiliations

¹ Department of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, 101 Roosevelt Ave, Eau Claire, WI, 54702, USA.
² Rigaku Americas Corporation, 9009 New Trails Drive, The Woodlands, TX, 77381, USA.

Abstract

The synthesis and the crystal structure of 1H-imidazole-1-methanol, C₄H₆N₂O, are described. This compound comprises an imidazole ring with a methanol group attached at the 1-position affording an imine nitro-gen atom able to receive a hydrogen bond and an alcohol group able to donate to a hydrogen bond. This imidazole methanol crystallizes with monoclinic (P2₁/n) symmetry with three symmetry-unique mol-ecules. These three mol-ecules are connected via O-H⋯N hydrogen bonding in a head-to-tail configuration to form independent three-membered macrocycles.

Keywords: crystal structure; hydrogen bonding; substituted imidazole.

Grants and funding

This work was funded by National Science Foundation grant MRI-2018561; University of Wisconsin-Eau Claire Office of Research and Sponsored Progams.