Modeling neurodegenerative disorders in zebrafish

Alim A Bashirzade; Konstantin N Zabegalov; Andrey D Volgin; Alisa S Belova; Konstantin A Demin; Murilo S de Abreu; Vladislav Ya Babchenko; Kseniya A Bashirzade; Konstantin B Yenkoyan; Maria A Tikhonova; Tamara G Amstislavskaya; Allan V Kalueff

doi:10.1016/j.neubiorev.2022.104679

Modeling neurodegenerative disorders in zebrafish

Neurosci Biobehav Rev. 2022 Jul:138:104679. doi: 10.1016/j.neubiorev.2022.104679. Epub 2022 Apr 28.

Affiliations

¹ Novosibirsk State University, Institute of Medicine and Psychology, Novosibirsk, Russia; Scientific Research Institute of Neuroscience and Medicine, Novosibirsk, Russia.
² Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
³ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Granov Scientific Research Center of Radiology and Surgical Technologies, St. Petersburg, Russia; Almazov Medical Research Center, St. Petersburg, Russia.
⁴ Moscow Institute of Physics and Technology, Moscow, Russia. Electronic address: abreu_murilo@hotmail.com.
⁵ Novosibirsk State University, Institute of Medicine and Psychology, Novosibirsk, Russia.
⁶ Neuroscience Laboratory, COBRAIN Center, M Heratsi Yerevan State Medical University, Yerevan, Armenia; COBRAIN Center - Scientific Educational Center for Fundamental Brain Research, Yerevan, Armenia.
⁷ The Russian Academy of Sciences, Moscow, Russia; Ural Federal University, Yekaterinburg, Russia; COBRAIN Center - Scientific Educational Center for Fundamental Brain Research, Yerevan, Armenia. Electronic address: avkalueff@gmail.com.

PMID: 35490912
DOI: 10.1016/j.neubiorev.2022.104679

Abstract

Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain disorders. Their complex pathogenesis commonly includes genetic and neurochemical deficits, misfolded protein toxicity, demyelination, apoptosis and mitochondrial dysfunctions. Albeit differing in specific underlying mechanisms, neurodegenerative disorders typically display evolutionarily conserved mechanisms across taxa. Here, we review the role of zebrafish models in recapitulating major human and rodent neurodegenerative conditions, demonstrating this species as a highly relevant experimental model for research on neurodegenerative diseases, and discussing how these fish models can further clarify the underlying genetic, neurochemical, neuroanatomical and behavioral pathogenic mechanisms.

Keywords: Cognitive deficits; Dementia; Neurodegenerative disorders; Rodents; Zebrafish.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Amyotrophic Lateral Sclerosis*
Animals
Humans
Neurodegenerative Diseases* / metabolism
Zebrafish