Pharmaceutical strategies for the treatment of bacterial biofilms in chronic wounds

Karan Razdan; Jorge Garcia-Lara; V R Sinha; Kamalinder K Singh

doi:10.1016/j.drudis.2022.04.020

Pharmaceutical strategies for the treatment of bacterial biofilms in chronic wounds

Drug Discov Today. 2022 Aug;27(8):2137-2150. doi: 10.1016/j.drudis.2022.04.020. Epub 2022 Apr 27.

Authors

Karan Razdan¹, Jorge Garcia-Lara², V R Sinha³, Kamalinder K Singh⁴

Affiliations

¹ School of Pharmacy and Biomedical Sciences, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK; Pharmaceutics Division, University Institute of Pharmaceutical Sciences, UGC-Centre of Advanced Study, Panjab University, Chandigarh 160014, India.
² School of Medicine, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK; UCLan Research Centre for Smart Materials, University of Central Lancashire, Preston PR1 2HE, UK; UCLan Research Centre for Translational Biosciences and Behavior, University of Central Lancashire, Preston PR1 2HE, UK.
³ Pharmaceutics Division, University Institute of Pharmaceutical Sciences, UGC-Centre of Advanced Study, Panjab University, Chandigarh 160014, India. Electronic address: vrsinha@pu.ac.in.
⁴ School of Pharmacy and Biomedical Sciences, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK; UCLan Research Centre for Smart Materials, University of Central Lancashire, Preston PR1 2HE, UK; UCLan Research Centre for Translational Biosciences and Behavior, University of Central Lancashire, Preston PR1 2HE, UK. Electronic address: ksingh1@uclan.ac.uk.

PMID: 35489675
DOI: 10.1016/j.drudis.2022.04.020

Abstract

Biofilms are sessile communities of microorganisms, mainly bacteria, that grow on biotic and abiotic surfaces. These microorganisms are embedded within an extracellular polymeric substance that provides enhanced protection from antimicrobials. Chronic wounds provide an ideal habitat for biofilm formation. Bacteria can easily attach to wound debris and can infect the wound due to an impaired host immune response. This review highlights the mechanism of biofilm formation and the role of biofilms in the pathophysiology of chronic wounds. Our major focus is on various formulation strategies and delivery systems that are employed to eradicate or disperse biofilms, thereby effectively managing acute and chronic wounds. We also discuss clinical research that has studied or is studying the treatment of biofilm-infected chronic wounds.

Keywords: Antibiofilm agents; Antimicrobial resistance; Bacterial infections; Biofilms; Chronic wounds; Drug delivery systems; Nanomaterials.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents* / administration & dosage
Anti-Bacterial Agents* / therapeutic use
Bacteria / drug effects
Biofilms / drug effects
Drug Delivery Systems
Extracellular Polymeric Substance Matrix*
Humans
Wound Infection* / drug therapy
Wound Infection* / microbiology

Substances

Anti-Bacterial Agents