Biomass-derived porous carbon with high drug adsorption capacity undergoes enzymatic and chemical degradation

Guohao Xu; Wenjuan Zhang; Juan Du; Xiaoling Yuan; Wenxiang Zhang; Wenfu Yan; Gang Liu

doi:10.1016/j.jcis.2022.04.064

Biomass-derived porous carbon with high drug adsorption capacity undergoes enzymatic and chemical degradation

J Colloid Interface Sci. 2022 Sep 15:622:87-96. doi: 10.1016/j.jcis.2022.04.064. Epub 2022 Apr 15.

Authors

Guohao Xu¹, Wenjuan Zhang¹, Juan Du², Xiaoling Yuan³, Wenxiang Zhang⁴, Wenfu Yan⁵, Gang Liu⁶

Affiliations

¹ State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China; Key Laboratory of Surface and Interface Chemistry of Jilin Province, College of Chemistry, Jilin University, Changchun, 130021, China.
² Key Laboratory of Preparation and Application of Environmental Friendly Materials, Ministry of Education, Jilin Normal University, Changchun, 130103, China.
³ Department of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China.
⁴ Key Laboratory of Surface and Interface Chemistry of Jilin Province, College of Chemistry, Jilin University, Changchun, 130021, China.
⁵ State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China.
⁶ State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China; Key Laboratory of Surface and Interface Chemistry of Jilin Province, College of Chemistry, Jilin University, Changchun, 130021, China. Electronic address: lgang@jlu.edu.cn.

PMID: 35489104
DOI: 10.1016/j.jcis.2022.04.064

Abstract

Degradability is a key safety issue when choosing materials for biomedical applications and environmental protection. This factor greatly limits the application of porous carbon in these areas due to the inert and stable nature of carbon network. In this work, this conflict could be well-resolved by rational designing a mesoporous carbon (MC) with biomass as a carbon source. The retained oxygen-containing species simultaneously increase drug adsorption capacity and the degradability of MC. The maximum adsorption quantity for doxorubicin over MC can reach 395.3 mg/g, about 3-fold over carbon nanotubes. The detailed analysis reveals that the degradation of MC occurs via a radical mediated oxidation process. The high electron density feature of MC facilitates the electrophilic addition reaction in the presence of HO. During this process, the carbon network is gradually degraded into fragments, carbon nanodots and ultimately to CO₂. This work opens up a new way to fabricate degradable porous materials and provides a promising material for the practical application in biomedical and environmental field.

Keywords: Adsorption; Biomass; Degradability; Porous carbon.

MeSH terms

Adsorption
Biomass
Nanotubes, Carbon*
Porosity

Substances

Nanotubes, Carbon