Freedom of expression: A synthetic route to metabolites

Hannah E Augustijn; Marnix H Medema

doi:10.1016/j.cell.2022.04.007

Freedom of expression: A synthetic route to metabolites

Cell. 2022 Apr 28;185(9):1449-1451. doi: 10.1016/j.cell.2022.04.007.

Authors

Hannah E Augustijn¹, Marnix H Medema²

Affiliations

¹ Bioinformatics Group, Wageningen University, Wageningen, The Netherlands; Institute of Biology, Leiden University, Leiden, The Netherlands.
² Bioinformatics Group, Wageningen University, Wageningen, The Netherlands; Institute of Biology, Leiden University, Leiden, The Netherlands. Electronic address: marnix.medema@wur.nl.

PMID: 35487188
DOI: 10.1016/j.cell.2022.04.007

Abstract

Microbial specialized metabolites play key roles in microbiome interactions, but their biosynthetic pathways are difficult to characterize. In this issue, Patel et al. (2022) describe new technologies for the computer-aided redesign of gene clusters to facilitate heterologous expression across diverse hosts and showcase their utility by identifying a new class of microbiome-derived nucleotide metabolites.

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MeSH terms

Biosynthetic Pathways*
Host Microbial Interactions*
Microbiota*