Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly. Studies have shown that acupuncture can effectively alleviate the symptoms of AD and slow down the disease progression, and its mechanism has been intensively explored. This paper summarized the researches on the mechanism of acupuncture intervention on AD in the past 5 years. It has been found that acupuncture intervention on AD is correlated with the regulation of the expression levels of relevant proteins, the inhibition of central inflammatory response, the resistance to oxidative stress injury, the modulation of brain energy metabolism, the improvement of neuronal synaptic plasticity, the adjustment of autophagy activity and the suppression of neuronal apoptosis.
阿尔茨海默病(AD)是一种老年人常见的神经退行性疾病。研究表明，针灸能有效减轻AD的症状，延缓病情进展，其作用机制研究也不断深入。本文总结了近5年针灸干预AD的机制研究资料，结果显示，针灸干预AD的作用机制与调节相关蛋白的表达、抑制中枢炎性反应、抵抗氧化应激损伤、调节脑区能量代谢、改善神经元突触可塑性、调控细胞自噬活性水平、抑制神经细胞凋亡密切相关。.
Keywords: Acupuncture; Alzheimer disease; Mechanism research; Review.