Ceftriaxone treatment failure in two cases of Enteric Fever caused by CTX-M15 positive Salmonella Typhi and its gastrointestinal carriage

Indian J Med Microbiol. 2022 Jul-Sep;40(3):459-461. doi: 10.1016/j.ijmmb.2022.04.001. Epub 2022 Apr 26.

Abstract

We report two cases of culture positive typhoid fever caused by ceftriaxone resistant Salmonella Typhi. Bacterial isolates from both the cases were positive for ESBL by phenotypic methods. Both patients didn't respond to ceftriaxone and were finally treated with meropenem. Screening of family members of one patient isolated a similar strain from a healthy carrier with the same antibiogram pattern. All isolates were subjected to PCR, which confirmed the presence of blaCTX-M15 ESBL gene. These two cases confirm emergence of ESBL-producing Salmonella Typhi causing Enteric Fever in India and also their presence in the gut flora of healthy carriers.

Keywords: CTX-M15; ESBL; Salmonella typhi.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Ceftriaxone / therapeutic use
  • Galanin / analogs & derivatives
  • Humans
  • Microbial Sensitivity Tests
  • Salmonella
  • Salmonella typhi*
  • Substance P / analogs & derivatives
  • Treatment Failure
  • Typhoid Fever* / diagnosis
  • Typhoid Fever* / drug therapy
  • Typhoid Fever* / microbiology

Substances

  • Anti-Bacterial Agents
  • galantide
  • Substance P
  • Ceftriaxone
  • Galanin

Supplementary concepts

  • Salmonella enterica subsp. enterica