Toxic reactive oxygen species enhanced chemodynamic therapy by copper metal-nanocellulose based nanocatalysts

Chaoqun You; Like Ning; Zhen Zhang; Hongshuai Wu; Qingli Qu; Fei Wang; Ranhua Xiong; Chaobo Huang

doi:10.1016/j.carbpol.2022.119432

Toxic reactive oxygen species enhanced chemodynamic therapy by copper metal-nanocellulose based nanocatalysts

Carbohydr Polym. 2022 Aug 1:289:119432. doi: 10.1016/j.carbpol.2022.119432. Epub 2022 Mar 31.

Authors

Chaoqun You¹, Like Ning¹, Zhen Zhang², Hongshuai Wu¹, Qingli Qu¹, Fei Wang¹, Ranhua Xiong³, Chaobo Huang⁴

Affiliations

¹ Jiangsu Co-Innovation Centre of Efficient Processing and Utilization of Forest Resources, Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
² SCNU-TUE Joint Lab of Device Integrated Responsive Materials (DIRM) and National Center for International Research on Green Optoelectronics, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China; ScienceK Ltd., Huzhou 313000, China.
³ Jiangsu Co-Innovation Centre of Efficient Processing and Utilization of Forest Resources, Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: ranhua.xiong@njfu.edu.cn.
⁴ Jiangsu Co-Innovation Centre of Efficient Processing and Utilization of Forest Resources, Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: huangchaobo@njfu.edu.cn.

PMID: 35483845
DOI: 10.1016/j.carbpol.2022.119432

Abstract

When compared with traditional petroleum-based materials, bio-based materials show greater application potential in the field of biomedicine owing to the good biocompatibility, in specifical, the application of natural macromolecular polymers in chemotherapeutics has become a hot topic in anticancer treatment. In this study, cellulose nanocrystals (CNCs) were selected as carriers, and Au nanoparticles (NPs) were directly conjugated on their surface, with the highly reactive Cu²⁺ ions serving as an ion-ligand bridge, to construct a multifunctional nanocatalyst. These findings suggest that the nanosystem delivers a large amount of highly reactive Cu²⁺ ions (3.75 wt%) and DOX (7.71 wt%) by the surface loading of cellulose nanocrystals, which greatly improves ROS yield and promotes the application of the Fenton reaction system in cancer therapy.

Keywords: Bio-based materials; Cellulose; Chemodynamic therapy; Drug carrier; Reactive oxygen species; Synergistic therapy.

MeSH terms

Cellulose
Copper* / chemistry
Gold / chemistry
Metal Nanoparticles* / chemistry
Polymers
Reactive Oxygen Species

Substances

Polymers
Reactive Oxygen Species
Gold
Copper
Cellulose