The huge clinical potential of microbiota in the treatment of pancreatic cancer: The next frontier

Zhilin Zhang; Dong Tang

doi:10.1016/j.bbcan.2022.188733

The huge clinical potential of microbiota in the treatment of pancreatic cancer: The next frontier

Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188733. doi: 10.1016/j.bbcan.2022.188733. Epub 2022 Apr 25.

Authors

Zhilin Zhang¹, Dong Tang²

Affiliations

¹ Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China.
² Department of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou, China. Electronic address: 83392785@qq.com.

PMID: 35483491
DOI: 10.1016/j.bbcan.2022.188733

Abstract

Microbes and their metabolites are found in all body organs; their interaction with body organs can influence inflammation, immunity, and cancer development. Pancreatic cancer development is closely related to intestinal, intrapancreatic, and oral flora. The microbiota plays a regulatory role in pancreatic cancer's malignant progression and treatment resistance. Thus, the study of microbiota-host interactions has emerged as a new hot topic in pancreatic cancer treatment, with microbiota control demonstrating significant clinical potential. This review summarizes recent advances in the clinical diagnosis and treatment of pancreatic cancer, emphasizing the enormous potential for operating microbiota in pancreatic cancer treatment.

Keywords: Clinical potential; Diagnosis; Microbiota; Pancreatic cancer; Treatment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Gastrointestinal Microbiome*
Humans
Microbiota*
Pancreas / pathology
Pancreatic Neoplasms* / pathology