Association of Neighborhood-Level Disadvantage With Neurofibrillary Tangles on Neuropathological Tissue Assessment

W Ryan Powell; Megan Zuelsdorff; Sarah A Keller; Tobey J Betthauser; Robert A Rissman; Barbara B Bendlin; Amy J H Kind

doi:10.1001/jamanetworkopen.2022.8966

Association of Neighborhood-Level Disadvantage With Neurofibrillary Tangles on Neuropathological Tissue Assessment

JAMA Netw Open. 2022 Apr 1;5(4):e228966. doi: 10.1001/jamanetworkopen.2022.8966.

Authors

W Ryan Powell¹, Megan Zuelsdorff^{2

3}, Sarah A Keller¹, Tobey J Betthauser^{2

4}, Robert A Rissman^{5

6}, Barbara B Bendlin^{1

2

4

7

8}, Amy J H Kind^{1

2

4}

Affiliations

¹ Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison.
² Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison.
³ University of Wisconsin School of Nursing, Madison.
⁴ Department of Medicine, Geriatrics Division, University of Wisconsin School of Medicine and Public Health, Madison.
⁵ Department of Neurosciences, University of California, San Diego.
⁶ Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla.
⁷ Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison.
⁸ Geriatric Research Education and Clinical Center, William S. Middleton Hospital, Department of Veterans Affairs, Madison, Wisconsin.

Abstract

This cross-sectional study evaluates income, educational level, employment status, and neighborhood and their association with brain changes in decedents with Alzheimer disease and related dementias.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Humans
Nervous System Diseases*
Neurofibrillary Tangles* / pathology
Neuropathology
tau Proteins

Substances

tau Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding