Indoleninyl-substituted pyrimido[1,2- b]indazoles via a facile condensation reaction

Abdul Qaiyum Ramle; Chee Chin Fei; Edward R T Tiekink; Wan Jefrey Basirun

doi:10.1039/d1ra04372b

Indoleninyl-substituted pyrimido[1,2- b]indazoles via a facile condensation reaction

RSC Adv. 2021 Jul 14;11(40):24647-24651. doi: 10.1039/d1ra04372b. eCollection 2021 Jul 13.

Authors

Abdul Qaiyum Ramle¹, Chee Chin Fei², Edward R T Tiekink³, Wan Jefrey Basirun¹

Affiliations

¹ Department of Chemistry, University of Malaya Kuala Lumpur 50603 Malaysia qaiyum@um.edu.my jeff@um.edu.my.
² Nanotechnology and Catalysis Research Centre, University of Malaya Kuala Lumpur 50603 Malaysia.
³ Research Centre for Crystalline Materials, School of Science and Technology, Sunway University Bandar Sunway Selangor Darul Ehsan 47500 Malaysia.

Abstract

A new series of pyrimido[1,2-b]indazoles bearing indolenine moieties was synthesized through a simple condensation reaction with up to 94% yield. The present method features the versatile formation of a pyrimidine ring with a broad range of substrates, great functional group compatibility and facile synthetic operation. The work offers opportunities in drug development as well as in materials science.