Solid phase extraction based on trimethylsilyloxy silica aerogel

V Lakshmi Prasanna; Igal Gozlan; Aviv Kaplan; Daniel Zachor-Movshovitz; Dror Avisar

doi:10.1039/d1ra01803e

Solid phase extraction based on trimethylsilyloxy silica aerogel

RSC Adv. 2021 May 24;11(30):18617-18622. doi: 10.1039/d1ra01803e. eCollection 2021 May 19.

Authors

V Lakshmi Prasanna¹, Igal Gozlan¹, Aviv Kaplan¹, Daniel Zachor-Movshovitz¹, Dror Avisar¹

Affiliation

¹ The Water Research Center, The Hydro-Chemistry Laboratory, Porter School for Environment and Earth Sciences, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University Tel Aviv 69978 Israel droravi@tauex.tau.ac.il.

Abstract

Solid-phase extraction (SPE) based on trimethylsilyloxy-modified silica aerogel was developed for extraction of chemotherapeutic drugs from water. The developed method is easy and affordable, can be performed in separating funnel and does not require a vacuum and SPE manifold. The extraction and recovery of cyclophosphamide (CYP), dexamethasone (DEX), and paclitaxel (TAX) by the aerogel from water were investigated. The factors governing the extraction efficiency such as sample pH, sample volume, volume of eluent and concentration of analytes were studied. The LOD and LOQ of the developed method were calculated and linearity was found in the range of 4-100 μg L^-1. The extraction efficiency of the aerogel was compared to that of other SPE cartridges, Oasis HLB, Strata-X-C, C18 and polymeric reversed phase, and the aerogel showed similar or better performance than the other commercial cartridges available on the market. The developed method was also used to extract chemotherapeutic drugs spiked in hospital wastewater.