Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

Shiyang Wang; Xiulin Wen; Ruimin Zhao; Yanxia Bai

doi:10.3389/fgene.2022.813823

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

Front Genet. 2022 Apr 11:13:813823. doi: 10.3389/fgene.2022.813823. eCollection 2022.

Authors

Shiyang Wang¹, Xiulin Wen², Ruimin Zhao¹, Yanxia Bai¹

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
² Department of Nursing, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Abstract

Background: Laryngeal cancer is more common in middle-aged and older men. We conducted an association analysis between ZNF208 polymorphisms and laryngeal cancer (LC) risk in the Northwestern Chinese Han male. Methods: A total of 352 subjects (172 LC patients and 180 controls) were involved in this study. Agena MassARRAY was used to determine the genotypes. Unconditional logistic regression analysis was performed to explore the relevance. Results: Two SNPs were associated with the risk of LC: rs8103163, OR = 1.41, p = 0.043; rs7248488, OR = 1.45, p = 0.025. Furthermore, rs8103163 was associated with an increased risk of LC under a log-additive model (OR = 1.40, p = 0.042), and rs7248488 was related to a higher risk of LC under a recessive model (OR = 2.33, p = 0.025) and a log-additive model (OR = 1.44, p = 0.026). Conclusions: We first demonstrated that the rs8103163 A allele and the rs7248488 A allele in ZNF208 create susceptibility to laryngeal cancer in the Northwestern Chinese Han male.

Keywords: Northwestern Chinese Han male; ZNF208 gene; case-control study; genetic variants; laryngeal cancer.