A novel superparamagnetic powerful guanidine-functionalized γ-Fe2O3 based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3 H)-one derivatives in Green media

Fateme Haji Norouzi; Naser Foroughifar; Alireza Khajeh-Amiri; Hoda Pasdar

doi:10.1039/d1ra05560g

A novel superparamagnetic powerful guanidine-functionalized γ-Fe₂O₃ based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3 H)-one derivatives in Green media

RSC Adv. 2021 Sep 7;11(48):29948-29959. doi: 10.1039/d1ra05560g. eCollection 2021 Sep 6.

Authors

Fateme Haji Norouzi¹, Naser Foroughifar¹, Alireza Khajeh-Amiri², Hoda Pasdar¹

Affiliations

¹ Department of Chemistry, Tehran North Branch, Islamic Azad University Tehran Iran n_foroughifar@yahoo.com.
² Toxicology Research Center, Aja University of Medical Sciences Tehran Iran.

Abstract

The novel organic-inorganic nanohybrid superparamagnetic (γ-Fe₂O₃@CPTMS-guanidine@SO₃H) nanocatalyst modified with sulfonic acid represents an efficient and green catalyst for the one-pot synthesis of quinazolin-4(3H)-one derivatives via three-component condensation reaction between anthranilic acid, acetic anhydride and different amines under microwave irradiation and solvent-free conditions (4a-q). XRD, FT-IR, FE-SEM, TGA, VSM and EDX were used to characterize this new magnetic organocatalyst. Outstanding performance, short response time (15-30 min), simple operation, easy work-up procedure, and avoidance of toxic catalysts can be regarded as its significant advantages. Moreover, it can be easily separated from the reaction solution through magnetic decantation using an external magnet, and recycled at least six times without notable reduction in its activity.