Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2 H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

Nicolai A Aksenov; Dmitrii A Aksenov; Igor A Kurenkov; Alexander V Aksenov; Anton A Skomorokhov; Lidiya A Prityko; Michael Rubin

doi:10.1039/d1ra02279b

Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2 H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

RSC Adv. 2021 Apr 30;11(27):16236-16245. doi: 10.1039/d1ra02279b.

Authors

Nicolai A Aksenov¹, Dmitrii A Aksenov¹, Igor A Kurenkov¹, Alexander V Aksenov¹, Anton A Skomorokhov¹, Lidiya A Prityko¹, Michael Rubin^{1

2}

Affiliations

¹ Department of Chemistry, North Caucasus Federal University 1a Pushkin St. Stavropol 355009 Russian Federation aaksenov@ncfu.ru.
² Department of Chemistry, University of Kansas 1567 Irving Hill Rd Lawrence KS 66045-7582 USA mrubin@ku.edu +1-785-864-5071.

Abstract

A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared via the previously known protocols, as 2-aminofuran derivatives were produced instead.