One pot synthesis of aryl nitriles from aromatic aldehydes in a water environment

Hongyan Lin; Ziling Zhou; Xiaopeng Ma; Qingqing Chen; Hongwei Han; Xiaoming Wang; Jinliang Qi; Yonghua Yang

doi:10.1039/d1ra03559b

One pot synthesis of aryl nitriles from aromatic aldehydes in a water environment

RSC Adv. 2021 Jul 9;11(39):24232-24237. doi: 10.1039/d1ra03559b. eCollection 2021 Jul 6.

Authors

Hongyan Lin^{1

2}, Ziling Zhou^{1

2}, Xiaopeng Ma^{1

2}, Qingqing Chen^{1

2}, Hongwei Han^{1

2}, Xiaoming Wang^{1

2}, Jinliang Qi^{1

2}, Yonghua Yang^{1

2}

Affiliations

¹ State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University Nanjing 210023 China qijl@nju.edu.cn yangyh@nju.edu.cn +86-25-89681381 +86-25-89681381.
² Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University Nanjing 210037 China.

Abstract

In this study, we found a green method to obtain aryl nitriles from aromatic aldehyde in water. This simple process was modified from a conventional method. Compared with those approaches, we used water as the solvent instead of harmful chemical reagents. In this one-pot conversion, we got twenty-five aryl nitriles conveniently with pollution to the environment being minimized. Furthermore, we confirmed the reaction mechanism by capturing the intermediates, aldoximes.