Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders

Yun Fan; Qinyue Zhao; Wencheng Xia; Youqi Tao; Wenbo Yu; Mingjia Chen; Yiqi Liu; Jue Zhao; Yan Shen; Yunpeng Sun; Chenfang Si; Shenqing Zhang; Yaoyang Zhang; Wensheng Li; Cong Liu; Jian Wang; Dan Li

doi:10.1038/s41422-022-00665-3

Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders

Cell Res. 2022 Jun;32(6):585-588. doi: 10.1038/s41422-022-00665-3. Epub 2022 Apr 27.

Authors

Yun Fan^#¹, Qinyue Zhao^#^{2

3}, Wencheng Xia^#^{4

5}, Youqi Tao^{2

3}, Wenbo Yu¹, Mingjia Chen¹, Yiqi Liu¹, Jue Zhao¹, Yan Shen¹, Yunpeng Sun^{4

5}, Chenfang Si^{4

5}, Shenqing Zhang^{2

3}, Yaoyang Zhang^{4

5}, Wensheng Li⁶, Cong Liu^{7

8}, Jian Wang⁹, Dan Li^{10

11

12}

Affiliations

¹ Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
² Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
³ Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁴ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
⁵ University of Chinese Academy of Sciences, Beijing, China.
⁶ Department of Anatomy and Histoembryology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
⁷ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. liulab@sioc.ac.cn.
⁸ University of Chinese Academy of Sciences, Beijing, China. liulab@sioc.ac.cn.
⁹ Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China. wangjian_hs@fudan.edu.cn.
¹⁰ Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. lidan2017@sjtu.edu.cn.
¹¹ Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. lidan2017@sjtu.edu.cn.
¹² Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, China. lidan2017@sjtu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Aged
Alzheimer Disease* / genetics
Amyloid
Dementia*
Humans
Membrane Proteins / genetics
Nerve Tissue Proteins
Parkinson Disease* / genetics

Substances

Amyloid
Membrane Proteins
Nerve Tissue Proteins
TMEM106B protein, human