Antifungal Macrolides Kongjuemycins from Coral-Associated Rare Actinomycete Pseudonocardia kongjuensis SCSIO 11457

Zhuangjie Fang; Qingbo Zhang; Liping Zhang; Jianglian She; Jie Li; Wenjun Zhang; Haibo Zhang; Yiguang Zhu; Changsheng Zhang

doi:10.1021/acs.orglett.2c01089

Antifungal Macrolides Kongjuemycins from Coral-Associated Rare Actinomycete Pseudonocardia kongjuensis SCSIO 11457

Org Lett. 2022 May 20;24(19):3482-3487. doi: 10.1021/acs.orglett.2c01089. Epub 2022 Apr 27.

Authors

Zhuangjie Fang^{1

2}, Qingbo Zhang^{1

2

3

4}, Liping Zhang^{1

3

4}, Jianglian She^{1

2}, Jie Li^{1

2

3

4}, Wenjun Zhang^{1

2

3

4}, Haibo Zhang^{1

2

3

4}, Yiguang Zhu^{1

2

3

4}, Changsheng Zhang^{1

2

3

4}

Affiliations

¹ Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
² University of Chinese Academy of Sciences, Beijing 100049, China.
³ Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.
⁴ Sanya Institute of Oceanology, SCSIO, Yazhou Scientific Bay, Sanya 572000, China.

PMID: 35476540
DOI: 10.1021/acs.orglett.2c01089

Abstract

Four new macrolides, kongjuemycins A and B1-B3 (1-4), were isolated from a coral-associated actinomycete Pseudonocardia kongjuensis SCSIO 11457. Their structures were characterized by comprehensive spectroscopic analysis and single-crystal X-ray diffraction. The absolute configurations of 1 and 2 were established by electronic circular dichroism calculation and the modified Mosher's method. Kongjuemycins displayed antifungal activity against three phytopathogenic fungi.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinobacteria*
Actinomycetales*
Animals
Anthozoa*
Anti-Bacterial Agents / chemistry
Antifungal Agents / pharmacology
Macrolides / chemistry
Molecular Structure
Pseudonocardia

Substances

Anti-Bacterial Agents
Antifungal Agents
Macrolides

Supplementary concepts

Pseudonocardia kongjuensis