Recent advances in modulation of cardiovascular diseases by the gut microbiota

J Hum Hypertens. 2022 Nov;36(11):952-959. doi: 10.1038/s41371-022-00698-6. Epub 2022 Apr 25.

Abstract

The gut microbiota has recently gained attention due to its association with cardiovascular health, cancers, gastrointestinal disorders, and non-communicable diseases. One critical question is how the composition of the microbiota contributes to cardiovascular diseases (CVDs). Insightful reviews on the gut microbiota, its metabolites and the mechanisms that underlie its contribution to CVD are limited. Hence, the aim of this review was to describe linkages between the composition of the microbiota and CVD, CVD risk factors such as hypertension, diet, ageing, and sex differences. We have also highlighted potential therapies for improving the composition of the gut microbiota, which may result in better cardiovascular health.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cardiovascular Diseases* / etiology
  • Cardiovascular System*
  • Diet
  • Female
  • Gastrointestinal Microbiome*
  • Humans
  • Hypertension* / etiology
  • Male