Experimental and simulation studies of localization and decoding of single and double dipoles

Hao Zhang; Minpeng Xu; Chen Zhang; Feng He; Xizi Song; Shanguang Chen; Xiqi Jian; Dong Ming

doi:10.1088/1741-2552/ac6a12

Experimental and simulation studies of localization and decoding of single and double dipoles

J Neural Eng. 2022 May 4;19(2). doi: 10.1088/1741-2552/ac6a12.

Authors

Hao Zhang¹, Minpeng Xu^{1

2}, Chen Zhang², Feng He^{1

2}, Xizi Song², Shanguang Chen^{1

2

3}, Xiqi Jian⁴, Dong Ming^{1

2}

Affiliations

¹ Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, People's Republic of China.
² Academy of Medical Engineering and Translational Medicine, Tianjin International Joint Research Centre for Neural Engineering, and Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, Tianjin 300072, People's Republic of China.
³ China Astronaut Research and Training Center, Beijing 100094, People's Republic of China.
⁴ School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, People's Republic of China.

PMID: 35468593
DOI: 10.1088/1741-2552/ac6a12

Abstract

Objective. Electroencephalography is a technique for measuring normal or abnormal neuronal activity in the human brain, but its low spatial resolution makes it difficult to locate the precise locations of neurons due to the volume conduction effect of brain tissue.Approach. The acoustoelectric (AE) effect has the advantage of detecting electrical signals with high temporal resolution and focused ultrasound with high spatial resolution. In this paper, we use dipoles to simulate real single and double neurons, and further investigate the localization and decoding of single and double dipoles based on AE effects from numerical simulations, brain tissue phantom experiments, and fresh porcine brain tissue experiments.Main results. The results show that the localization error of a single dipole is less than 0.3 mm, the decoding signal is highly correlated with the source signal, and the decoding accuracy is greater than 0.94; the location of double dipoles with an interval of 0.4 mm or more can be localized, the localization error tends to increase as the interval of dipoles decreases, and the decoding accuracy tends to decrease as the frequency of dipoles decreases.Significance. This study localizes and decodes dipole signals with high accuracy, and provides a technical method for the development of EEG.

Keywords: acoustoelectric effect; decoding; electroencephalography; localization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Mapping / methods
Brain* / physiology
Computer Simulation
Electroencephalography* / methods
Head
Swine