Methylation of the HCBP6 promoter is associated with primary biliary cholangitis pathogenesis

Lili Gao; Yijin Zhang; Xuesong Gao; Li Xu; Xuefei Duan

doi:10.1016/j.bbrc.2022.03.080

Methylation of the HCBP6 promoter is associated with primary biliary cholangitis pathogenesis

Biochem Biophys Res Commun. 2022 Jun 25:610:176-181. doi: 10.1016/j.bbrc.2022.03.080. Epub 2022 Apr 14.

Authors

Lili Gao¹, Yijin Zhang¹, Xuesong Gao¹, Li Xu¹, Xuefei Duan²

Affiliations

¹ Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, No.8, Jingshun East Street, Chaoyang District, Beijing, 100015, China.
² Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, No.8, Jingshun East Street, Chaoyang District, Beijing, 100015, China. Electronic address: duanxuefei@ccmu.edu.cn.

PMID: 35468421
DOI: 10.1016/j.bbrc.2022.03.080

Abstract

Hepatitis C virus core-binding protein 6 (HCBP6), first characterized in our laboratory and also referred to as FUNDC2, is involved in lipid and glucose metabolism, platelet activation, and platelet survival. Here we demonstrate that hypermethylation of mitochondrial HCBP6 is linked Primary Biliary Cholangitis (PBC) pathogenesis. Serum and liver levels of HCBP6 in PBC patients were reduced in comparison with controls. Further research confirmed a correlation between CpG1 hypermethylation and HCBP6 levels. Taken together, our results reveal another new feature of HCBP6.

Keywords: HCBP6; Methylation; Pathological stag; Primary biliary cholangitis.

MeSH terms

Autophagy-Related Proteins* / genetics
DNA Methylation*
Humans
Liver Cirrhosis, Biliary*
Mitochondrial Proteins* / genetics
Promoter Regions, Genetic

Substances

Autophagy-Related Proteins
Mitochondrial Proteins