Progressive Application of Marine Biomaterials in Targeted Cancer Nanotherapeutics

Curr Pharm Des. 2022;28(41):3337-3350. doi: 10.2174/1381612828666220422091611.

Abstract

The marine microenvironment harbors many unique species of organisms that produce a plethora of compounds that help mankind cure a wide range of diseases. The diversity of products from the ocean bed serves as potentially healing materials and inert vehicles carrying the drug of interest to the target site. Several composites still lay undiscovered under the blue canopy, which can provide treatment for untreated diseases that keep haunting the earth periodically. Cancer is one such disease that has been of interest to several eminent scientists worldwide due to the heterogenic complexity involved in the disease's pathophysiology. Due to extensive globalization and environmental changes, cancer has become a lifestyle disease continuously increasing exponentially in the current decade. This ailment requires a definite remedy that treats by causing minimal damage to the body's normal cells. The application of nanotechnology in medicine has opened up new avenues of research in targeted therapeutics due to their highly malleable characteristics. Marine waters contain an immense ionic environment that succors the production of distinct nanomaterials with exceptional character, yielding highly flexible molecules to modify, thus facilitating the engineering of targeted biomolecules. This review provides a short insight into an array of marine biomolecules that can be probed into cancer nanotherapeutics sparing healthy cells.

Keywords: Heterogenic complexity; biomaterials; cancer-therapeutics; marine; marine biomaterials; nano-therapeutics.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials
  • Humans
  • Nanostructures*
  • Nanotechnology
  • Neoplasms* / drug therapy
  • Tumor Microenvironment

Substances

  • Biocompatible Materials