Self-assembling figure-of-eight and pseudoplectoneme aromatic oligoamide ribbons

Chem Commun (Camb). 2022 May 10;58(38):5789-5792. doi: 10.1039/d2cc01696f.

Abstract

Two oligoamide macrocycles composed of eight and twelve 7-amino-8-fluoro-2-quinolinecarboxylic acid monomers were synthesised despite the propensity of their acyclic precursors to fold and self-assemble into double helices. Macrocyclisations were made possible through the transient use of helicity disruptors. The resulting macrocyclic ribbons were found to adopt figure-of-eight and pseudoplectoneme shapes that maintain an ability to self-assemble.

MeSH terms

  • Amides*
  • Protein Structure, Secondary

Substances

  • Amides