Intron retention: importance, challenges, and opportunities

Justin J-L Wong; Ulf Schmitz

doi:10.1016/j.tig.2022.03.017

Intron retention: importance, challenges, and opportunities

Trends Genet. 2022 Aug;38(8):789-792. doi: 10.1016/j.tig.2022.03.017. Epub 2022 Apr 21.

Authors

Justin J-L Wong¹, Ulf Schmitz²

Affiliations

¹ Epigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown 2050, Australia; Faculty of Medicine and Health, The University of Sydney, Camperdown 2050, Australia.
² Department of Molecular & Cell Biology, College of Public Health, Medical & Vet Sciences, James Cook University, Townsville 4811, Australia; Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns 4878, Australia. Electronic address: ulf.schmitz@jcu.edu.au.

PMID: 35466008
DOI: 10.1016/j.tig.2022.03.017

Abstract

Recent landmark discoveries have underpinned the physiological importance of intron retention (IR) across multiple domains of life and revealed an unexpected breath of functions in a large variety of biological processes. Despite significant progress in the field, some challenges remain. Once solved, opportunities will arise for discovering more functions of IR.

Keywords: RNA processing; alternative splicing; epi-transcriptomics; intron retaining transcripts; splicing regulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alternative Splicing*
Biological Phenomena*
Introns / genetics