The Impact of Obesity in Heart Failure

Salvatore Carbone; Carl J Lavie; Andrew Elagizi; Ross Arena; Hector O Ventura

doi:10.1016/j.ccl.2021.12.009

The Impact of Obesity in Heart Failure

Cardiol Clin. 2022 May;40(2):209-218. doi: 10.1016/j.ccl.2021.12.009.

Authors

Salvatore Carbone¹, Carl J Lavie², Andrew Elagizi², Ross Arena³, Hector O Ventura⁴

Affiliations

¹ Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 1020 W Grace St, 500 Academic Centre, Room 113c, Richmond, VA 23220, USA; Department of Internal Medicine, Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad St, Richmond, VA 23219, USA. Electronic address: scarbone@vcu.edu.
² John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA.
³ Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor Street, Chicago, IL 60612, USA; TotalCardiology Research Network, Calgary, Alberta, Canada.
⁴ Cardiomyopathy and Heart Transplantation, Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA.

PMID: 35465895
DOI: 10.1016/j.ccl.2021.12.009

Abstract

Overweight and obesity adversely impact cardiac structure and function, affecting systolic and diastolic ventricular function. Epidemiologic studies have documented an obesity paradox in large heart failure cohorts, where overweight and obese individuals with established heart failure have a better short- and medium-term prognosis compared with leaner patients; this relationship is strongly impacted by level of cardiorespiratory fitness. There are implications for therapies aimed at increasing lean mass as well as weight loss and improvements in quality of diet for the prevention and treatment of heart failure and concomitant obesity to improve cardiorespiratory fitness.

Keywords: Body composition; Cardiorespiratory fitness; Heart failure; Obesity; Obesity paradox.

Publication types

Review

MeSH terms

Body Mass Index
Heart Failure* / complications
Heart Failure* / epidemiology
Humans
Obesity / complications
Obesity / epidemiology
Overweight* / complications
Prognosis
Weight Loss