Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers

Ying Liang; Yuan Xu; Yaoyao Tong; Yue Chen; Xilu Chen; Shimin Wu

doi:10.3389/fchem.2022.883627

Graphene-Based Electrochemical Sensor for Detection of Hepatocellular Carcinoma Markers

Front Chem. 2022 Apr 8:10:883627. doi: 10.3389/fchem.2022.883627. eCollection 2022.

Authors

Ying Liang¹, Yuan Xu², Yaoyao Tong¹, Yue Chen¹, Xilu Chen¹, Shimin Wu¹

Affiliations

¹ Center for Clinical Laboratory, General Hospital of the Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, China.
² Center for Clinical Laboratory, Wuhan Hospital of Chinese Medicine, Wuhan, China.

Abstract

Hepatocellular carcinoma (HCC) is a group of highly lethal malignant tumors that seriously threaten human health. The main way to improve the survival quality and reduce the mortality of HCC is early diagnosis and treatment. Therefore, it will be of great significance to explore new quantitative detection methods for HCC markers. With the rapid development of electrochemical biosensors and nanomaterials, electrochemical sensors based on graphene can detect tumor markers, with the advantages of simple operation, high detection sensitivity, and specificity. Combined with the published literature in recent years, the article briefly reviews the application of graphene-based electrochemical biosensors in the detection of HCC markers, including alpha-fetoprotein (AFP), Golgi protein-73 (GP73), exosomes, and microRNA-122 (miR-122).

Keywords: electrochemical sensor; graphene; hepatocellular carcinoma; nanometer material; tumor markers.

Publication types

Review